possible down regulation of the p16 gene promoter in individuals with hepatocellular carcinoma
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Possible Down Regulation of the p16 Gene Promoter in Individuals with Hepatocellular Carcinoma
BACKGROUND The p16 tumor suppressor gene is an important negative regulator of the cell cycle. Inactivation of p16, especially via promoter hypermethylation, has been found in numerous human cancers such as breast, lung, colorectal, and liver. OBJECTIVES To determine the role of epigenetic methylation in p16 regulation in Iranian patients with hepatocellular carcinoma (HCC). PATIENTS AND ME...
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full textPromoter hypermethylation of the p16 gene is associated with poor prognosis in recurrent early-stage hepatocellular carcinoma.
Despite significant advances in the detection and treatment of hepatocellular carcinoma, the prognosis of patients with hepatocellular carcinoma remains very poor, in part due to the high incidence of recurrence. This study was aimed at identifying a prognostic indicator of recurrence in patients with hepatocellular carcinoma. We retrospectively analyzed CpG island hypermethylation of the p14, ...
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Journal title:
hepatitis monthlyجلد ۱۱، شماره ۹، صفحات ۷۱۹-۷۲۳
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